Rinse and pat dry chuck roast and cut into small cubes. If using beef stew meat slice into smaller portions.
Place the beef in a bowl and add the following: 2 tbsp olive oil, Worcestershire sauce, garlic powder, onion powder, Italian seasoning, salt, and black pepper. Next mix in flour and coat well on all pieces.
In a large dutch oven, on medium-heat, add 2 tbsp olive oil. When the hot, sear the beef on both sides for 2-3 minutes each until golden brown. Remove the meat from the pan and set aside in a bowl.
In the dutch oven, add 2 tbsp olive oil, chopped celery, onions and minced garlic. Sauté until soft (4-5 minutes). Stir in tomato paste and beef base and simmer for 3 minutes. Add the red wine and water. Next add the fresh or dried herbs (thyme, rosemary, and bay leaves/oregano).
Cover the dutch oven and lower the heat to medium-low. Simmer for 2 hours.
After 2 hours, if necessary shred the meat into smaller chunks. Add the carrots and potatoes, and simmer on medium-low for an additional 30 minutes. Next add frozen mixed vegetables and simmer for 10 minutes.